Endocrine Abstracts

Reproduction is a very energy costly function for the organism and, therefore, very tightly regulated by central and peripheral cues that ultimately determine the proper pattern of kisspeptin and GnRH release. Among these, metabolic cues play a critical role in the control of reproductive function, through the interplay of satiety and hunger signals. Further, the interaction between reproductive and metabolic functions is bidirectional, as kisspeptin has also emerged as a nove...

Puberty is a tightly regulated process through which an individual attains reproductive capability. An intricate network of central and peripheral factors play a role in this process; however, the cellular and molecular events that initiate and sustain adult reproductive function remain largely unknown. Recently, kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have been shown to be gate-keepers of puberty...

Introduction: Treculia Africana (TA) has been used as an anti-inflammatory agent by the Yoruba people of West Africa and is also known to be a component of an ancient anti-diabetic remedy used in the Western and Middle belt areas of Nigeria. This study was conducted to investigate the anti-hyperglycemic property of the aqueous seed extract of Treculia Africana (TAE) and also to evaluate the potential of this extract in reversing the toxicity inflicted by expe...

Introduction: Garcinia cambogia is a plant with reported spermatogenic properties. ciprofloxcin is an antibiotic used in the treatment of of various bacterial infection but with reported toxic effects on the testes. The modulatory effects of Garcinia cambogia on ciprofloxacin-induced testicular toxicity was evaluated in this study.Method: Twenty one (21) male Wistar rats were randomly divided into four (4) groups. Group A was given ciprofloxacin...

Introduction: The objective of this Report is to evaluate for a possible association between serum uric acid levels and PAD in persons with diabetes mellitus.Methods: This was a cross sectional Study carried out in 232 DM patients, Anthropometric indices and ankle brachial pressure indices were documented. Biochemical analyses were carried out for lipid parameters, glycosylated haemoglobin and uric acid.Results: The mean age and ag...

Objective: Growth hormone (GH) deficiency in adult patients is associated with poor quality of life and increased cardiovascular morbidity and mortality. We studied the effects of GH replacement on the lipid profile in adult patients with GH deficiency treated over a 3-year period.Method: A retrospective analysis of 70 adult patients, who had completed 3 years of GH therapy. Growth hormone is initiated at a dose of 0.3 mg/day and titrated to 0.5 mg/day o...

Case history: A 28 year-old male of British origin was referred with a one-year history of a left-sided chest mass and an abnormal chest X-ray. He was otherwise fit and well, had a past medical history of vitiligo and had no relevant family history. His physical examination revealed some hypopigmented spots on his skin, several tattoos across his back and a firm mass on his left upper chest, which was mildly tender on palpation. He had no other palpable masses.<p class="ab...

Background: Acromegaly is characterized by hormonal excess of GH and IGF-1, however many patients suffer from hypopituitarism as a result from either disease or treatment. Quality of Life (QoL) is known to be reduced both in acromegaly, with mixed results on the role of biochemical control herein, and hypopituitarism. Studies report the level of surgery-induced hypopituitarism after acromegaly at 12.79% (CI 9.88–16.00%). Treatment of acromegaly aimed at normalization of h...

Anacardium occidentale is a multi-purpose tree of the anacardae family with great economic and medicinal value. The leaf of the tree has been reported to possess hypoglycaemic and anti-diabetic properties. However, literature is devoid of any molecular basis for the potent effects observed. This study evaluated the molecular mechanisms underlying the efficacy and safety of the leaves by investigating glucagon-like peptide 1, insulin and kidney injury molecule genes us...

The dampening of hypothalamic–pituitary–adrenal (HPA) axis responses to a repeated stress is termed HPA habituation. We investigated here the effects of two commonly used repeated restraint stress paradigms, in which rats are exposed either to 10 episodes of 0.5 h restraint or 5 episodes of 3 h restraint. We compared ACTH, corticosterone, and testosterone responses, as well as corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA levels within bra...